解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:INTRODUCTION:In transgenic animal models of sepsis, members of the Bcl-2 family of proteins regulate lymphocyte apoptosis and survival of sepsis. This study investigates the gene regulation of pro-apoptotic and anti-apoptotic members of the Bcl-2 family of proteins in patients with early stage severe sepsis. METHODS:I...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7088
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:We conducted an ultrasound study to investigate echocardiographic artifacts in mechanically ventilated patients with lung pathology. METHODS:A total of 205 mechanically ventilated patients who exhibited lung atelectasis and/or pleural effusion were included in this 36-month study. The patients underwent l...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7021
更新日期:2008-01-01 00:00:00
abstract::The pathogenesis of septic acute kidney injury (AKI) is not well understood. In the present issue of Critical Care, the combined clinical and experimental study from Mariano's group provides new insight into the disease. The study shows that plasma from septic burn patients with acute renal failure initiated pro-apopt...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc6798
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to the Tie2 receptor protects the vasculature from inflammation and leakage, whereas binding of Ang-2 antago...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7130
更新日期:2008-01-01 00:00:00
abstract::The aim of perioperative haemodilution is to reduce loss of red blood cells during elective surgery. The oncotic and molecular characteristics of the various plasma substitutes employed determine how effectively normovolaemia is maintained, and their non-oncotic effects include alterations in microvascular perfusion. ...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc6892
更新日期:2008-01-01 00:00:00
abstract::Decreased renal drug clearance is an obvious consequence of acute kidney injury (AKI). However, there is growing evidence to suggest that nonrenal drug clearance is also affected. Data derived from human and animal studies suggest that hepatic drug metabolism and transporter function are components of nonrenal clearan...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7093
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc6999
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Prognosis in patients suffering out-of-hospital cardiac arrest is poor. Higher survival rates have been observed only in patients with ventricular fibrillation who were fortunate enough to have basic and advanced life support initiated soon after cardiac arrest. An ability to predict cardiac arrest outcome...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7009
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Subarachnoid haemorrhage (SAH) may damage the hypothalamo-pituitary-adrenal gland (HPA) axis and disturb cortisol metabolism. There are no available data that relates to the response of the HPA axis in the acute phase of SAH. We aimed to characterise the behavior of serum adrenocorticotropic hormone (ACTH)...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7084
更新日期:2008-01-01 00:00:00
abstract::An influenza pandemic threatens to be the most lethal public health crisis to confront the world. Physicians will have critical roles in diagnosis, containment and treatment of influenza, and their commitment to treat despite increased personal risks is essential for a successful public health response. The obligation...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6918
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The aim of this study, conducted in 2006, was to find out whether changes in sedation management in German intensive care units took place in comparison with our survey from 2002. METHODS:We conducted a follow-up survey with a descriptive and comparative cross-sectional multi-center design. A postal survey ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc6189
更新日期:2007-01-01 00:00:00
abstract::Infusing arginine vasopressin (AVP) in advanced vasodilatory shock is usually accompanied by a decrease in cardiac index and systemic oxygen transport. Whether or not such a vasoconstriction impedes regional blood flow and thus visceral organ function, even when low AVP is used, is still a matter of debate. Krejci and...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc6171
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that other nonlactate, unmeasured anions contribute to this type of acidosis. METHODS:Eleven anesthetized dogs were hemorrhaged to a mean arterial press...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6200
更新日期:2007-01-01 00:00:00
abstract::High-mobility group box 1 (HMGB1) is a DNA-binding protein that also exhibits proinflammatory cytokine-like activity. HMGB1 is passively released by necrotic cells and also is actively secreted by immunostimulated macrophages, dendritic cells, and enterocytes. Although circulating HMGB1 levels are increased relative t...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6088
更新日期:2007-01-01 00:00:00
abstract::Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and prevent propagation of thrombin generation and formation of microvascular thrombosis. Furthermore, it may simu...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6154
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Identification of bacterial infections is crucial if treatment is to be initiated early and antibiotics used rationally. The primary objective of this study was to test the efficiency of procalcitonin (PCT) in identifying bacterial/parasitic episodes among febrile adult patients presenting to an emergency ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5926
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The current shortage of accurate and readily available, validated biomarkers of disease severity in sepsis is an important limitation when attempting to stratify patients into homogeneous groups, in order to study pathogenesis or develop therapeutic interventions. The aim of the present study was to determ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,多中心研究
doi:10.1186/cc5783
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Temperature management is used with increased frequency as a tool to mitigate neurological injury. Although frequently used, little is known about the optimal cooling methods for inducing and maintaining controlled normo- and hypothermia in the intensive care unit (ICU). In this study we compared the efficac...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc6104
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:There is limited information on whether the incidence of acute kidney injury (AKI) in critically ill patients has changed over time and there is controversy on whether its outcome has improved. METHODS:We interrogated the Australian New Zealand Intensive Care Society Adult Patient Database to obtain data ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5949
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Prophylactic steroid therapy to reduce the occurrence of postextubation laryngeal edema is controversial. Only a limited number of prospective trials involve adults in an intensive care unit. The purpose of this study was to ascertain whether administration of multiple doses of dexamethasone to critically ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc5957
更新日期:2007-01-01 00:00:00
abstract::Mechanotransduction holds the underlying mechanisms of ventilator-induced lung injury. Research on this subject, however, could be difficult for clinicians, especially when results are controversial. A recent study by Li and co-workers is used as an example, to explain how to critically read literatures related to bas...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6131
更新日期:2007-01-01 00:00:00
abstract::Cellular hypoxia is a fundamental mechanism of injury in the critically ill. The study of human responses to hypoxia occurring as a consequence of hypobaria defines the fields of high-altitude medicine and physiology. A new paradigm suggests that the physiological and pathophysiological responses to extreme environmen...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc5142
更新日期:2007-01-01 00:00:00
abstract::Relatively simple measures of echocardiography and Doppler, as left ventricular end-systolic area and volume, should be taken in consideration when performing a Doppler echocardiographic examination, as they could have both clinical and prognostic value. ...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6129
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The aim of life-support measures in brain-dead donors is to preserve the functional value of their organs. In renal transplantation, serum creatinine level is one of the criteria for graft harvest. The aim of this study was to assess the impact of intensive care on donor renal function through two criteria: ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6120
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:We compared the effects of mechanical ventilation with a lower tidal volume (V(T)) strategy versus those of greater V(T) in patients with or without acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) on the use of opioids and sedatives. METHODS:This is a secondary analysis of a previously ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5969
更新日期:2007-01-01 00:00:00
abstract::Progress in management of critically ill neurological patients has led to improved survival rates. However, severe residual neurological impairment, such as persistent coma, occurs in some survivors. This raises concerns about whether it is ethically appropriate to apply aggressive care routinely, which is also associ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6107
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Previous studies have shown through theoretical analyses that the ratio of the partial pressure of oxygen in arterial blood (PaO2) to the inspired oxygen fraction (FiO2) varies with the FiO2 level. The aim of the present study was to evaluate the relevance of this variation both theoretically and experimen...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6174
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The overall prognosis of critically ill patients with cancer has improved during the past decade. The aim of this study was to identify early prognostic factors of intensive care unit (ICU) mortality in patients with cancer. METHODS:We designed a prospective, consecutive, observational study over a one-ye...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5721
更新日期:2007-01-01 00:00:00
abstract::Tight glycaemic control has emerged as a major focus in critical care. However, the struggle to repeat, improve and standardize the results of the initial landmark studies is ongoing. The prospective computerized glycaemic control study by Shulman et al. highlights two emerging and often overlooked aspects of intensiv...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6099
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Severe acute pancreatitis (SAP) requiring admission to a critical care unit is associated with high mortality and long lengths of stay. We describe the case mix, outcome, and activity of admissions with SAP who were identified from a high-quality clinical database. METHODS:We conducted a secondary analysi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5682
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The respiratory variation in pulse pressure (PP) has been established as a dynamic variable of cardiac preload which indicates fluid responsiveness in mechanically ventilated patients. The impact of acute changes in cardiac performance on respiratory fluctuations in PP has not been evaluated until now. We ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc5779
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the incidence of organ failure in trauma patients treated in an intensive care unit (ICU), and to study the relationship between organ failure and long-term survival and functional status. METHODS:This is a cohort study of all adult ICU trauma patients admitted to a unive...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6111
更新日期:2007-01-01 00:00:00
abstract::Mechanical ventilation associated lung injury (VALI) negatively impacts the outcomes of critically ill patients. Research during the past two decades has led to a better understanding of key physiologic mechanisms of injury, yet uncertainty over the topographical distribution of these mechanisms continues to fuel cont...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc6160
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Little is known about the development of acute lung injury outside the intensive care unit. We set out to document the following: the association between predefined clinical conditions and the development of acute lung injury by using the American-European consensus definition; the frequency of lung injury d...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6113
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the clinical usefulness of open lung biopsy (OLB) in patients undergoing mechanical ventilation for diffuse pulmonary infiltrates of unknown etiology. METHODS:This was a 10-year retrospective study in a 10-bed medical intensive care unit. The medical records of 36 v...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6106
更新日期:2007-01-01 00:00:00
abstract::Even more than in previous disasters, Katrina has proven itself to be a testing ground for a plethora of new technologies. Although not all of these technologies did immediately save lives, in this regard a number of them exhibited considerable potential for the future, and hence there is a need to include them in fut...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3945
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION:An increasing body of evidence from laboratory and clinical studies suggests that vasopressin may represent a promising alternative vasopressor for use during cardiac arrest and resuscitation. Current guidelines for cardiopulmonary resuscitation recommend the use of adrenaline (epinephrine), with vasopress...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3967
更新日期:2006-02-01 00:00:00
abstract:INTRODUCTION:The ventilator and the endotracheal tube impose additional workload in mechanically ventilated patients breathing spontaneously. The total work of breathing (WOB) includes elastic and resistive work. In a bench test we assessed the imposed WOB using 3100 A/3100 B SensorMedics high-frequency oscillatory ven...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc3988
更新日期:2006-02-01 00:00:00
abstract::The epidemiology of severe acute renal failure has dramatically changed in the past decade. Its leading cause is sepsis and the syndrome develops mostly in the intensive care unit as part of multiple organ dysfunction syndrome. After the significant improvements obtained from the mid 1970s to the mid 1990s, the past d...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc4843
更新日期:2006-02-01 00:00:00
abstract::The use of controlled mechanical ventilation (CMV) in patients who experience weaning failure after a spontaneous breathing trial or after extubation is a strategy based on the premise that respiratory muscle fatigue (requiring rest to recover) is the cause of weaning failure. Recent evidence, however, does not suppor...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc3917
更新日期:2006-02-01 00:00:00